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A Phase I Dose Escalation and Dose Expansion and Phase II Monotherapy Open-Label, First-In-Human, Multicenter Study of OP-1250 in Adult Subjects with Advanced and/or Metastatic Hormone Receptor (HR)-Positive, HER2-negative Breast Cancer (Olema Pharmaceuticals OP-1250-001)

Study Details

OP-1250 is a small molecule Complete Estrogen Receptor ANtagonist (CERAN). OP-1250 potently competes with the endogenous activating estrogenic ligand 17-beta estradiol for binding in the ligand binding pocket. OP-1250 blocks estrogen-driven transcriptional activity, inhibits estrogen-driven breast cancer cell growth, and induces degradation of the estrogen receptor.

Learn More

ClinicalTrials.gov NCT number
NCT04505826

Principal Investigators

  • Steve Lo, MD
Sponsor(s)
Olema Pharmaceuticals
Contact
Mary Miller, LPN at 203-358-8879
or officeofresearch@stamhealth.org

Location

  • Bennett Cancer Center
    One Hospital Plaza
    Stamford, CT 06902
    Main: 203-276-2695

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